Current Trends in Experimental and Computational Approaches to Combat Antimicrobial Resistance

Antifungal resistance: current trends and future strategies to combat

Antifungal resistance represents a major clinical challenge to clinicians responsible for treating invasive fungal infections due to the limited arsenal of systemically available antifungal agents. In addition current drugs may be limited by drug-drug interactions and serious adverse effects/toxicities that prevent their prolonged use or dosage escalation. Fluconazole resistance is of particula...

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches.

Databases and chemo- and bioinformatics tools that contain genomic, proteomic and functional information have become indispensable for antimicrobial drug research. The combination of chemoinformatics tools, bioinformatics tools and relational databases provides means of analyzing, linking and comparing online search results. The development of computational tools feeds on a diversity of discipl...

Novel Strategies to Combat Antimicrobial Resistance

Infectious diseases form the major health-care burden for the developing world and antimicrobials prove to be the magical drugs to combat this. The discovery of antimicrobial agents was boon for the global health-care system and the wonderful cure by antimicrobials shifted the disease trends from infectious to life-style diseases in the developed world. Sudden appearance of the antimicrobial re...

trends in antimicrobial resistance

Prescribing and guidelines: both must improve to combat antimicrobial resistance.

Most human exposure occurs through antimicrobial prescription in the community, the most common reason for which is presumed respiratory infection. Human exposure varies widely between European countries, with the same patient being, on average, four times more likely to receive an antibiotic in France compared to the Netherlands [1]; a difference that cannot be explained by the scientific evid...